Uveitis associated with EVD had previously only been described in four survivors of a small EVD outbreak in the Democratic Republic of the Congo in 1995 1. Epidemiologic and clinical characterization newly identified uveitis as particularly common and consequential to EVD survivor’s lives. The extent of this outbreak, with 28,652 reported cases and 11,325 deaths, making it the largest recorded, enabled the clinical phenotyping of sequelae in large numbers of EVD survivors.
High resolution the persistence of memory driver#
The association of persistent EBOV RNA as a potential driver of severe immunopathology has pathophysiologic implications for understanding, preventing, and mitigating vision-threatening uveitis in EVD survivors.Ĭlinical sequelae in Ebola virus disease (EVD) survivors received urgent clinical, public health, and research attention, for the first time systematically, during and following the 2013–2016 outbreak that occurred in Western Africa. Here we show the clinical natural history, resultant ocular pathology, intraocular antigen-specific antibody detection, and persistent intraocular EBOV RNA detected long after clinical resolution. In a rhesus monkey survivor of experimental Ebola virus (EBOV) infection, we observed and documented the clinical, virologic, immunologic, and histopathologic features of severe uveitis. Absent sampling of human intraocular fluids and tissues, these questions might be investigated in animal models of disease however, challenges intrinsic to the nonhuman primate model and the animal biosafety level 4 setting have historically limited inquiry. Ian Crozier ORCID: /0000-0003-2485-4011 1, 6Ĭommunications Biology volume 5, Article number: 1204 ( 2022)ĭespite increasing evidence that uveitis is common and consequential in survivors of Ebola virus disease (EVD), the host-pathogen determinants of the clinical phenotype are undefined, including the pathogenetic role of persistent viral antigen, ocular tissue-specific immune responses, and histopathologic characterization.Persistent intraocular Ebola virus RNA is associated with severe uveitis in a convalescent rhesus monkey
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